Bioinformatic Research Group in Epidemiology

Statistical methods for multi-omics and environmental factors data analysis and integration

At the Bioinformatic Research Group in Epidemiology, we develop statistical methods and software for genomics, transcriptomics and exposomics to be applied in environmental epidemiology. We focus on SNP arrays and next generation sequencing. We are interested in leveraging our expertise in handling both, epidemiological and genomic data, to help translate scientific research into biomedical practice. The group follows open research rules and make every possible effort to make our research reproducible and openly available.

Focusing on

Developing statistical methods and tools to deal with 'omic' and exposome data
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Next Generation Sequencing
Developing analysis tools and statistical methods to detect mosaicims and analyze RNA-seq data
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Genomic Inversions
Developing analysis tools and new statistical methods to detect inversions using SNParray data and a...
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CNVs and imputed SNPs
Developing models to incorporate uncertainty in genetic association studies
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Genetic mosaicisms and health
We have developed a new method to detect genetic mosaicisms using SNP array data ([MAD](http://brge....
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Our Team


October 31, 2017
This package was built when I was working at Xavier Estivill’s lab at Center for Genomic Regulation and it is written in collaboration with Victor Moreno and his colleagues. The R package SN
August 31, 2017
rexposome is an R package for exposome characterization and exposome-outcome test association. It was developed by Carles Hernandez-Ferrer as part of its PhD project and used in the analysis...
August 31, 2017
The *Comparative Toxicogenomics Database* is a public resource for toxicogenomic information manually curated from the peer-reviewed scientific literature about chemicals, gene and health ou...
August 31, 2017
This R package is built to extend the capabilities of the R package rexposome and to allow to find exposome molecular signatures. This is archived by implementing a limma wrapper that works ...
MAD (Mosaic Alteration Detector)
July 31, 2017
This is a joint work with Benjamin Rodriguez-Santiago (qGenomics) and Luis Pérez-Jurado (UPF). MAD is a software tool to detect mosaic events from SNP arrays using BAF and LRR values. The al
July 31, 2017
`inveRsion` is an R package for the detection of genetic inversions using SNP-array data. This is a joint collaboration with Alejandro Caceres (ISGlobal) and Suzanne Sindi (Center for Comput...
July 31, 2017
`tweeDEseq` is an R package for analyzing RNAseq count data. It implements Poisson-Tweedie family of distributions to model count data distribution. This family includes Poisson and Negative...
July 31, 2017
Joint with Alejandro Cáceres (ISGlobal), we have developed a method that can be applied to common GWAS for calling the inversion genotypes, which accounts for population stratification when
July 31, 2017
This is a joint work with Roderic Guigó's group - Bioinformatics and Genomics program, Center for Genomic Regulatio (CRG). This R package is designed to compare transcript relative expressio