`tweeDEseq` is an R package for analyzing RNAseq count data. It implements Poisson-Tweedie family of distributions to model count data distribution. This family includes Poisson and Negative Bionomial as particular cases. The testPT test is used to detect genes that are deferentially expressed (DE).
The methods are described in the manuscript published at BMC Bioinformatics:
> *Esnaola M, Puig P, Gonzalez D, Castelo R, Gonzalez JR. A flexible count data model to fit the wide diversity of expression profiles arising from extensively replicated RNA-seq experiments. BMC Bioinformatics 2013, 14:254.*
The manuscript illustrates the performance of our proposed method using a real RNA-seq data set comprising 69 Nigerian. We have created an experimental data pacakge (tweeDEseqCountData) that is available at Bioconductor.
`tweeDEseq` is available from Bioconductor:
* **Bioconductor**: [`tweeDEseq`](http://bioconductor.org/packages/release/bioc/html/tweeDEseq.html)